The neighbourhood borders on the residential areas of Brasa, Teika, Purvciems, Avotu Street and the Central District. The borders run along Artilērijas, Krāsotāju, Lienes, Augusta Deglava Streets, the railway line, and Brīvības, Tallinas and Aleksandra Čaka Streets.
The Grīziņkalns neighbourhood covers the total area of 1517 km², which is about 30% of an average neighbourhood in Rīga. The area has a perimeter of 5547 meters. Notwithstanding the fact that Grīziņkalns lies within the jurisdiction of two executive authorities of the city districts, the borders of the Grīzinķalns neighbourhood can be regarded as objective enough to define the area (the only potential adjustment could be drawing the Grīzinķalns border along Tallinas Street instead of Artilērijas Street). A distinctive feature of Grīzinķalns is the lack of a single centre, and separate areas within the neighbourhood have different functions. For instance, the Grīziņkalns Park is the neighbourhood’s central public space; the Daugava Stadium and related structures is the major sports centre for the neighbourhood’s south-eastern part, while sports activities in the north-eastern sector focus around the University Stadium and the Daugava Sports House; main streets are the hubs for business operations, and the like.